Complement C5-IN-1 (Compound 7) 是补体成分蛋白5 (C5) 的小分子抑制剂。 Complement C5-IN-1 与 C5 相互作用以防止其被 C5 转化酶切割, 阻断酵母多糖诱导的 50%人全血 MAC 沉积的 IC50 值为 0.77 μM。
产品描述
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
体外活性
Complement C5-IN-1 (Compound 7) interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood (IC50: 0.77 μM)[1].
Cas No.
2365402-67-9
分子式
C24H32N2O6
分子量
444.52
储存和溶解度
DMSO:90mg/mL (202.5mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years