您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > PDM2
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PDM2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PDM2图片
CAS NO:688348-25-6
包装与价格:
包装价格(元)
10 mg电议
50 mg电议
100 mg电议

产品介绍
PDM2 是一种有效的选择性芳烃受体 (AhR) 拮抗剂,Ki为 1.2±0.4 nM。

产品描述

PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.

体外活性

In a previous screening study, it was found that the replacement of resveratrol hydroxyls by the same substituent produced compounds with the following order of affinity: OH (resveratrol) , OMe< F< CF3< Cl (PDM 2). PDM 2 exhibited a Ki of 1.25 for AhR and no affinity for ER, indicating that replacement of hydroxyl with chloride could abolish binding on ER and dramatically increase the affinity for AhR. Moreover, among its analogs PDM 2 was the most potent AhR antagonists in this series, being 10-fold more efficient than resveratrol. PDM 2, devoid of measurable affinity for ER, did not display any effect on ER-driven transcription. Therefore, PDM 2 was considered as a selective AhR modulator with regard to ER. In addition, its trimethoxylated derivatives and 3,5-methoxy derivatives were able to induce cytotoxicity at doses lower than 100 nM, which was consistent with previous data. 3,5-Methoxy derivatives, however, only showed cytotoxicity at concentrations higher than 10 μM [1].

Cas No.

688348-25-6

分子式

C14H9Cl3

分子量

283.58

储存和溶解度

DMSO:50 mg/mL (176.32 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years