Nigericin sodium salt 是来自吸水链霉菌的抗生素，是一种 NLRP3 激活剂。Nigericin sodium 是一种阳离子离子载体，可抑制高尔基体功能并抑制革兰氏阳性菌的生长。 它还可以防止病毒激活并触发 NALP3 炎性体的激活。

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. It also prevents viral activation and triggers activation of the NALP3 inflammasome.

A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM), significantly decreased cytosolic pH (0.1-1 nM) and significantly increased Fluo3 fluorescence (0.1-10 nM).?Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance.?The effect of nigericin on annexin V binding was significantly blunted, but not abolished by removal of extracellular Ca(2+).?The nigericin-induced increase in [Ca(2+)]i and annexin V binding was again significantly blunted but not abolished by the Na(+)/H(+) exchanger inhibitor cariporide (10 μM).?Nigericin triggers eryptosis, an effect paralleled by ROS formation, in part dependent on stimulation of Ca(2+) entry, and involving the cariporide-sensitive Na(+)/H(+) exchanger[1].

28643-80-3

C40H67NaO11

746.94

尼日利亚菌素;尼日利亚菌素钠盐

Ethanol:47 mg/mL (62.92mM)
Methanol:122 mg/mL (163.33mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years