CORM3 是一种 CO 释放分子，能够减少NLRP3炎症小体的激活，可以减弱NF-Κb p65的核异位，减少 ROS 的生成，并提高细胞内谷胱甘肽和超氧化物歧化酶的水平。

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]

CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]

475473-26-8

C5H4ClNO5Ru

294.61

(OC-6-44)-三羰基氯(甘氨酸基)钌;CORM3

DMSO:129 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years