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Molsidomine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Molsidomine图片
CAS NO:25717-80-0
包装与价格:
包装价格(元)
50 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
吗多明
SIN-10
Morsydomine
Corvaton
产品介绍
MolsIDOmine是一种长效的、口服活性的血管扩张药,在肝脏中代谢可被为活性代谢物LinsIDOmine。 其中LinsIDOmine是一种不稳定的化合物,能够产生NO,可用作血管舒张剂。

产品描述

Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

体内活性

Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart[1].

Cas No.

25717-80-0

分子式

C9H14N4O4

分子量

242.235

别名

吗多明;SIN-10;Morsydomine;Corvaton

储存和溶解度

DMSO:45 mg/mL (185.8 mM)
Ethanol:21 mg/mL(86.7 mM)
H2O:9 mg/mL (37.15 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years