HS271 是一种 IRAK4 选择性抑制剂，IC50 为 7.2 μM。

HS271 is a selective inhibitor of IRAK4 with an IC50 of 7.2 μM.

In rat models of LPS-induced TNFα production collagen-induced arthritis, HS271 (15-150 mg/kg) shows robust antiinflammatory efficacy with a t1/2 of 3.3 h and Cmax of 2107 ng/mL. The oral bioavailability of HS271 is 67.3%, 58.2%, 14.4&% and 49% in mice, rats, dogs, and monkeys, respectively[1].

2410393-15-4

C21H24F3N5O2

435.44

DMSO:90 mg/mL (206.7 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years