Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone highly potently inhibits PGHS-2 (IC50= 0.19 μM) but is much less highly potent with PGHS-1 (IC50=20 μM). References: [1]. Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45. [2]. Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85.

纯度：≥98%

CAS：139226-28-1