| CAS NO: | 1186195-60-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1186195-60-7 |
| 别名 | 3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐 |
| 化学名 | 2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole;hydrochloride |
| Canonical SMILES | CC1=NC(=CS1)C#CC2=CN=CC=C2.Cl |
| 分子式 | C11H9ClN2S |
| 分子量 | 236.72 |
| 溶解度 | DMF: 3 mg/ml,DMSO: 15 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 5 nM MTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist. The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8). mGluR5 belonging to group I is excitatory, mainly localized at the edge of axo-spinous and axodendritic synaptic junctions. In vitro: Like MPEP, MTEP showed a nanomolar affinity for mGluR5, but seemed to be superior to MPEP in term of specificity. MTEP did not influence mGluR2, mGluR7, NMDA, AMPA or kainate receptors, while inhibited MAOA at a concentration three times higher than MPEP. Moreover, recent study indicated that MTEP was five times stronger that MPEP as an anxiolytic compound [1]. In vivo: MTEP with doses between 0.5 and 3 mg/kg was found to decrease the haloperidol-induced muscle rigidity, which was measured as an increased muscle resistance of the rat hind leg. The longest and strongest effect was observed with the dose of 1 mg/kg. MTEP was also found to reduce the haloperidol-induced increase in electromyographic activity recorded in the tibialis anterior and gastrocnemius muscles. 3 and 5 mg/kg of MTEP could inhibit the haloperidol- induced catalepsy [1]. Clinical trial: N/A Reference: |
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