BMS-1001 hydrochloride 是一种人PD-L1/PD-1免疫检查点的抑制剂，具有口服活性且细胞毒性低。

BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes.

BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. It presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1.

2113650-04-5

C35H35ClN2O7

631.12

DMSO:11.5 mg/mL(18.22 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years