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mGlu2 agonist
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
mGlu2 agonist图片
CAS NO:1311385-32-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
200mg电议

产品介绍
mGlu2 激动剂是 2812223 的丙氨酸前药，是一种选择性和有效的正构 mGlu2 受体激动剂。
Cas No.1311385-32-6
别名(1R,2S,4R,5R,6R)-2-[[(2S)-2-氨基-1-氧代丙基]氨基]-4-(1H-1,2,4-三唑-5-基硫基)-双环[3.1.0]己烷-2,6-二甲酸铵盐水合物
化学名(1R,2R,4S,5R,6R)-4-[[(2S)-2-aminopropanoyl]amino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; azane; hydrate
Canonical SMILESCC(C(=O)NC1(CC(C2C1C2C(=O)O)SC3=NC=NN3)C(=O)O)N.N.O
分子式C13H22N6O6S
分子量390.42
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.IC50 Value:Target: mGluR

References:
[1]. http://clinicaltrials.gov/ct2/show/NCT01383967
[2]. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D.Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.Neuropharmacology. 2012 Mar 15.
[3]. Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D.Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 recepto
[4]. Liu W, Downing AC, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54.
[5]. Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate