L-161982 是 EP4 受体的特异性拮抗剂。

L-161982 is a selective antagonist of the EP4 receptor.

In squamous carcinoma Tca8113 cells, L-161982 induces apoptosis and cell cycle arrest, and inhibits prostaglandin E2-induced proliferation [2]. L-161982 (10 μM) blocks PGE2-stimulated cell proliferation of HCA-7 cells and ERK phosphorylation[3].

In collagen-induced arthritis (CIA) mice model, L-161982 (5 mg/kg; i.p.) reduces arthritis lesions and lesion progression. L-161982 shows less joint swelling and lower arthritis score after 35 days post immunization[1].

147776-06-5

C32H29F3N4O4S2

654.72

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years