STAT5 Inhibitor 是STAT5的抑制剂，对 STAT5β 亚型的IC50值为 47 μM。

STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.

The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins that are implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.

285986-31-4

C16H11N3O3

293.282

STAT5 Inhibitor

DMSO:23.0 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years