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STAT5-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
STAT5-IN-1图片
CAS NO:285986-31-4
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
STAT5 Inhibitor
产品介绍
STAT5 Inhibitor 是STAT5的抑制剂,对 STAT5β 亚型的IC50值为 47 μM。

产品描述

STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.

体外活性

The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins that are implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.

Cas No.

285986-31-4

分子式

C16H11N3O3

分子量

293.282

别名

STAT5 Inhibitor

储存和溶解度

DMSO:23.0 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years