Pimozide 是多巴胺受体拮抗剂，对多巴胺 D1、D2 和 D3 受体的Ki值分别为 588、1.4 和 2.5 nM。它也是STAT3和STAT5的抑制剂，对 α1 肾上腺素受体也有较高亲和性，Ki值为 39 nM。

Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of the motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors.

2062-78-4

C28H29F2N3O

461.557

匹莫奇特;匹莫齐特;R6238

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years