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Y-39983 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Y-39983 hydrochloride图片
CAS NO:471843-75-1
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
盐酸Y-39983
Y-33075 HCl
SNJ-1656
RKI-983
Y-39983 HCl
产品介绍
Y-39983 hydrochloride是一种选择性的Rho-associated coiled coil-forming protein kinase (ROCK)抑制剂。

产品描述

Y-39983 hydrochloride is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor.

体内活性

In rabbits, topical administration of Y-39983 significantly increased conventional outflow by 65.5%, followed by significant, dose-dependent reduction in IOP. Maximum IOP reduction was 13.2 ± 0.6 mm Hg (mean ± SE) at 0.1% Y-39983 in rabbits. In monkeys, at 3 hours after topical administration of 0.05% Y-39983, maximum reduction of IOP was 2.5 ± 0.8 mm Hg. No serious side effects were observed in ocular tissues except sporadic punctate subconjunctival hemorrhage during long-term topical administration of Y-39983 four times a day (at 2-hour intervals) in rabbits or monkeys. However, punctate subconjunctival hemorrhage was not observed with administration twice daily (at a 6-hour interval) or three times a day (at 5-hour intervals)[1].

Cas No.

471843-75-1

分子式

C16H17ClN4O

分子量

316.79

别名

盐酸Y-39983;Y-33075 HCl;SNJ-1656;RKI-983;Y-39983 HCl

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years