IWP-O1 是Porcn抑制剂，在 L-Wnt-STF 细胞中的EC50值为 80 pM。它能够抑制Wnt蛋白分泌，可以抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.

IWP-O1functions by preventing the secretion of Wnt proteins. IWP-O1 effectively suppressed the phosphorylation of Dvl2/3 in HeLa cells. At the same time, the phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6). IWP-O1 suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM.

2074607-48-8

C26H20N6O

432.487

DMSO:100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years