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Porcn-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Porcn-IN-1图片
CAS NO:2036044-77-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Porcupine-IN-1
产品介绍
Porcupine-IN-1 是一种有效的Porcupine抑制剂(IC50:0.5±0.2 nM)。

产品描述

Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).

体外活性

Porcupine is an enzyme that catalyzes the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell-based STF reporter gene assay. Porcupine-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor[1].

体内活性

Porcupine-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg)[1].

细胞实验

HEK293T cells are transfected with pLinbin-Wnt3A plasmid or vehicle control. The HEK293T cells are then treated with or without compounds (Porcupine-IN-1). Western Blot is used after 48 h to analyze both the cell lysis and culture medium[1].

Cas No.

2036044-77-4

分子式

C25H19FN4O

分子量

410.452

别名

Porcupine-IN-1

储存和溶解度

DMSO:100 mg/mL (243.64 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years