GNF-6231是一个强的，有选择性的，能够口服的Porcupine抑制剂能够阻止Wnt信号通路。

GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.

GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested[1].

GNF-6231 has favorable potency and a PK profile across preclinical species upon oral administration. The reference for orally in MMTV-Wnt1 tumor-bearing mice is dosed at 3 mg/kg. GNF-6231 showed very robust dose-related antitumor efficacy[1].

1243245-18-2

C24H25FN6O2

448.49

DMSO:36mg/mL (80.3mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years