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PY-60
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
PY-60 有效激活针对膜联蛋白 A2 (Kd = 1.4 μM) 的 YAP 转录活性。 PY-60 在能够通过增殖重塑表皮的成年动物中激活促增殖、依赖于 YAP 的转录程序。

产品描述

PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 μM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation.

体外活性

PY-60 robustly increased the levels of YAP-controlled transcripts (that is, ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (that is, MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1). PY-60 induced luciferase activity in 293A-TEAD-LUC cells in the presence or absence of serum when cells were plated at high cell density with EC50s of 1.5 and 1.6 μM, respectively. PY-60 also promoted the association of YAP and TEAD proteins in cells in a dose-dependent manner and induced the nuclear localization of YAP in response to increased cell density[1].

体内活性

PY-60 (10 uM) promoted a dramatic expansion of keratinocytes and K14-positive precursors. PY-60 resulted in an approximate doubling of epidermal thickness, a result derived from an increased number of keratinocytes per unit length of skin[1].

Cas No.

T9566

分子式

C16H15N3O2S

分子量

313.37

储存和溶解度

DMSO:95 mg/mL (303.16 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years