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LEQ506
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LEQ506图片
CAS NO:1204975-42-7
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
NVP-LEQ506
产品介绍
LEQ506 是一种 Smo 抑制剂,对 hSmo 和 mSmo 的 IC50 分别为 2 nM 和 4 nM。

产品描述

LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

体外活性

LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1[1]. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[2].

Cas No.

1204975-42-7

分子式

C25H32N6O

分子量

432.56

别名

NVP-LEQ506

储存和溶解度

DMSO:100 mg/mL (231.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years