NGP555 是 γ-分泌酶调节剂。
产品描述
NGP555 is a modulator of γ-secretase.
体外活性
NGP555 effectively lowers Aβ42 in cell cultures (9 nM) and increasing shorter forms of Aβ at the same time .
体内活性
NGP555 also shows good oral bioavailability and is brain-penetrant with a brain: plasma ratio of ~0.93 in mice. NGP555-treated Tg mice show significant protection from a decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 obviously lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post-dose. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above .
Cas No.
1304630-27-0
分子式
C23H23FN4S
分子量
406.52
储存和溶解度
DMSO:25 mg/mL (61.50 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years