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NGP555
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NGP555图片
CAS NO:1304630-27-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
NGP555 是 γ-分泌酶调节剂。

产品描述

NGP555 is a modulator of γ-secretase.

体外活性

NGP555 effectively lowers Aβ42 in cell cultures (9 nM) and increasing shorter forms of Aβ at the same time .

体内活性

NGP555 also shows good oral bioavailability and is brain-penetrant with a brain: plasma ratio of ~0.93 in mice. NGP555-treated Tg mice show significant protection from a decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 obviously lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post-dose. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above .

Cas No.

1304630-27-0

分子式

C23H23FN4S

分子量

406.52

储存和溶解度

DMSO:25 mg/mL (61.50 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years