您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > GANT 58
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
GANT 58
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GANT 58图片
CAS NO:64048-12-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
NSC 75503
4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
产品介绍
GANT 58 是GLI拮抗剂,能够抑制 GLI1 诱导的转录,其IC50=5 μM。

产品描述

GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).

体外活性

GANT58 is a downstream inhibitor of Hh signaling and it also is an indeed inhibitor of Hh signaling downstream of Smo and Sufu. GANT58 potently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth using human prostate cancer cells harboring downstream activation of the Hh pathway[1]. GANT58 has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species) and it has been shown to inhibit GLI transactivation[2]. GANT58 mainly acts at the nuclear level because transcription induced by GLI1 with a mutated nuclear export signal is still blocked.

体内活性

Nude mice are treated with every second-day s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). Although mice treated with these compounds showed no such signs of toxicity, this protocol is also introduced for the GANTs to be able to compare all compounds. All injections are done 2-3 cm away from the tumors. Suppression of tumor cell growth is observed for all compounds, during an 18-day treatment period. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size[1].

Cas No.

64048-12-0

分子式

C24H16N4S

分子量

392.48

别名

NSC 75503;4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine

储存和溶解度

DMSO:9.09 mg/mL (23.16 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years