CP 31398 dihydrochloride 是一种 p53 稳定剂,可稳定 p53 的活性构象并促进具有突变型或野生型 p53 的癌细胞系中的 p53 活性。
产品描述
CP 31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
体外活性
CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells[1]. CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells[2].
Cas No.
1217195-61-3
分子式
C22H28Cl2N4O
分子量
435.39
别名
CP 31398 dihydrochloride
储存和溶解度
DMSO:6 mg/ml (13.78 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years