Hexamethylene amiloride是 amiloride 的衍生物，也是 Na+/H+交换抑制剂，可降低白血病细胞的细胞内 pH (pHi) 并诱导凋亡。

HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 μM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 μM.

1428-95-1

C12H18ClN7O

311.77

5-（N，N-六亚甲基）阿米洛利;HMA-5;5-HMA;Hexamethylene amiloride;5-(N,N-Hexamethylene)amiloride

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years