GSK481 是一种选择性，特异性RIP1抑制剂，其IC50值为 1.3 nM，可抑制野生型人RIP1中的 Ser166磷酸化，IC50值为 2.8 nM。它对 U937 细胞的IC50值为 10 nM。

GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.

GSK481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells. GSK481 has approximately equivalent RIP1 FP potencies against human and cynomolgus monkey RIP1 but was >100-fold less potent against nonprimate RIP[1].

1622849-58-4

C21H19N3O4

377.4

GSK'481

DMSO:70 mg/mL (185.5 mM)
Ethanol:<1 mgml
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years