RIPK1-IN-7 是一种选择性有效的 RIPK1 抑制剂，Kd值为 4 nM，IC50值为 11 nM。在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.

In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).

2300982-44-7

C25H22F3N5O2

481.47

DMSO:60 mg/mL (124.62 mM),Need ultrasonic
H2O:0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years