GSK3145095 是一种口服有效的 RIPK1 抑制剂，IC50 为 5 nM，具有潜在的免疫调节活性和抗肿瘤活性。

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.

GSK3145095 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking RIP1 kinase-dependent cellular responses.?Highlighting its potential as a novel cancer therapy, the inhibitor was also able to promote a tumor suppressive T cell phenotype in pancreatic adenocarcinoma organ cultures.

1622849-43-7

C20H17F2N5O2

397.38

DMSO:245mg/ml (616.54 Mm),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years