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SJ-172550
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SJ-172550图片
CAS NO:431979-47-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
SJ-172550 是 MDMX 的小分子抑制剂,EC50为5 μM。

产品描述

SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).

体外活性

SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates [1][2].

Cas No.

431979-47-4

分子式

C22H21ClN2O5

分子量

428.87

储存和溶解度

DMSO:33.33 mg/mL (77.72 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years