AST 487 是RET激酶抑制剂 (IC50:880 nM),能够抑制 RET 自磷酸化,及下游效应器激活,也抑制FLT-3 (IC50:520 nM)。
产品描述
AST 487 is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
Cas No.
630124-46-8
分子式
C26H30F3N7O2
分子量
529.568
别名
NVP-AST 487
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years