Gossypol 是一种多酚醛，可渗透细胞并作为几种脱氢酶的抑制剂。它分别与BCL-xL蛋白和BCL-2蛋白结合，Ki值分别为 0.5-0.6 μM 和 0.2-0.3 mM。

Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner[1]. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro[2].

MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference)

303-45-7

C30H30O8

518.55

棉籽酚;Pogosin;棉酚;BL 193;NSC 56817

DMSO:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years