Cucurbitacin IIA 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。

1. Cucurbitacin IIA can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.

58546-34-2

C32H50O8

562.744

Dihydrocucurbitacin Q1;葫芦素Iia;Curcurbitacin IIA;Hemslecin A

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:91 mg/mL(161.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years