GDP366 有效且特异性地抑制 Survivin 和 Op18 的表达。 GDP366 增加染色体不稳定性，并通过抑制端粒酶活性诱导细胞衰老。

GDP366, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. a dual inhibitor of survivin and Op18.

GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis[1].

501698-03-9

C20H17N5OS

375.45

DMSO:62.5 mg/mL (166.47 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years