AtorvaSTATin hemicalcium salt 是一种口服有效的 HMG-CoA 还原酶抑制剂 ，可用作降低胆固醇的药物。它抑制人 SV-SMC 增殖和侵袭，IC50分别为 0.39 μM 和 2.39 μM。

Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.

在statin处理过的大鼠中,Atorvastatin降低p22phox和NOX1血管mRNA的表达,同时提高主动脉过氧化氢酶的表达.在胆固醇喂养的兔子中,Atorvastatin抑制C反应蛋白的血清水平的增加.

在血管平滑肌细胞中, Atorvastatin（0.1 μM）能够抑制血管紧张素Ⅱ和肿瘤坏死因子-α诱导的NF-κB活化；Atorvastatin（1 μM）减少血管紧张素Ⅱ和肿瘤坏死因子-α诱导的IP-10的表达。

Briefly, SV-SMC from 5 different patients are seeded into 24-well cell culture plates at a density of 1×104?cells per well in full growth medium. Cells are incubated overnight and then quiesced in serum free medium for 3 days before transfer to full growth medium (10% FCS) containing 5 different statins (simvastatin, atorvastatin, fluvastatin, lovastatin, and pravastatin)at a range of concentrations. All statins are tested on cells from each individual patient. Medium and drugs are replaced after 2 days, and viable cell numbers are determined in triplicate wells after 4 days using Trypan Blue and a hemocytometer. The increase in cell number is calculated by subtracting the starting cell number (day 0) from the final cell number (day 4). Data are then normalized to control values (no statin) to correct for differences in proliferation rates between cells from different patients.

134523-03-8

C66H68CaF2N4O10

1155.363

CI-981;Lipitor;Sortis;Atorvastatin Calcium;Atorvastatin hemicalcium;阿托伐他汀钙

DMSO:57.8 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years