Verapamil hydrochloride 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。

Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.

Verapamil可以抗心律失常,减少大鼠心脏氧的消耗,并保存Cx43蛋白.

Verapamil和Diltiazem能够基本上抑制重组CES2的水解酶活性(Ki分别为0.25 ± 0.02、3.84 ± 0.99 μM)。

Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1].

152-11-4

C27H39ClN2O4

491.07

Calcan hydrochloride;(±)-Verapamil hydrochlorid;Manidon;盐酸维拉帕米;Verapamil HCl

DMSO:24.6 mg/mL (50 mM)
H2O:24.6 mg/mL (50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years