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Filorexant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Filorexant图片
CAS NO:1088991-73-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
MK-6096
产品介绍
Filorexant 是一种口服有效且选择性可逆的 OX1 和 OX2 受体拮抗剂,Ki值小于3nM。
Filorexant occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. Filorexant demonstrated effective binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), in radioligand binding and functional cell-based assays. It has no significant off-target activities against a panel of >170 receptors and enzymes [1].

产品描述

Filorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki<3 nM).

体外活性

Filorexant occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. Filorexant demonstrated effective binding and antagonism of both human OX(1)R and OX(2)R (<3 nm in binding, 11 flipr), radioligand binding and functional cell-based assays. it has no significant off-target activities against a panel of>170 receptors and enzymes [1].

体内活性

Filorexant dose-dependently decreased locomotor activity and obviously enhanced sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg)[1].

Cas No.

1088991-73-4

分子式

C24H25FN4O2

分子量

420.48

别名

MK-6096

储存和溶解度

DMSO:100 mg/mL (237.82 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years