Amitriptyline 是一种具有镇痛特性的三环类抗抑郁药 (TCA)。它广泛用于治疗抑郁症和神经性疼痛。
产品描述
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain.
体外活性
Amitriptyline inhibits both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline is also an inhibitor of histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively.
Cas No.
50-48-6
分子式
C20H23N
分子量
277.4
储存和溶解度
H2O:9.7 mg/mL (34.96 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years