您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Epiberberine chloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Epiberberine chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Epiberberine chloride图片
CAS NO:889665-86-5
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
表小檗碱氯化物
Epiberberine (chloride)
盐酸表小檗碱
产品介绍
Epiberberine chloride 是一种从黄连中得到的生物碱,是一种AChE和BChE抑制剂,和非竞争性的BACE1抑制剂。它具有抗氧化作用,能够清除 ONOO-,可用于研究阿尔滋海默症和糖尿病。

产品描述

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).

体外活性

Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3].

体内活性

Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days).

Cas No.

889665-86-5

分子式

C20H18ClNO4

分子量

371.82

别名

表小檗碱氯化物;Epiberberine (chloride);盐酸表小檗碱

储存和溶解度

DMSO:7.4 mg/mL (19.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years