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Org-26576
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Org-26576图片
CAS NO:1026791-61-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Org-26576 是 AMPA 受体的一种正变构调节剂。

产品描述

Org-26576 is a positive allosteric modulator of the AMPA receptor.

体外活性

Org-26576 shows selectivity for AMPA receptors when tested at 10 μM against >60 molecular targets including G-Protein Coupled Receptors, ion channels, and kinases. Org-26576 represents structurally a distinct chemical series derived from the first generation ampakine CX516 and shows 10-30 fold greater potency when compared to CX516 in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 μM in rat hippocampal primary cultured neurons [1].

体内活性

Org-26576 (Chronic administration) increases progenitor cell proliferation in the dentate gyrus (approximately 40%) and in the prelimbic cortex (approximately 35%) at the 10-mg/kg dosage. Cells born in response to chronic Org-26576 in dentate gyrus show increased rates of survival (approximately 30%) with the majority of surviving cells expressing a neuronal phenotype. Org-26576 (1 mg/kg) produces obviously enhances the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus, and CA3 subfield of the hippocampus in mice. AMPA receptor potentiation by Org-26576 exerts a positive modulatory influence on brain-derived neurotrophic factor (BDNF) expression during ongoing neuronal activity. Total BDNF mRNA levels are significantly increased in the hippocampus of animals exposed to the combination of Org-26576 and stress[1][2][3].

Cas No.

1026791-61-6

分子式

C11H12N2O2

分子量

204.23

储存和溶解度

DMSO:25 mg/mL (122.41 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years