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AH 6809
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AH 6809图片
CAS NO:33458-93-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
AH 6809 是 EP 和 DP 受体的拮抗剂，对克隆的人 EP1、EP2、EP3-III 和 DP 受体的 Kis 分别为 1217、1150、1597 和 1415 nM。
Cas No.33458-93-4
别名6-异丙氧基-9-氧代氧杂蒽-2-羧酸,AH6809;AH-6809
化学名9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid
Canonical SMILESCC(C)OC1=CC2=C(C=C1)C(=O)C3=C(O2)C=CC(=C3)C(=O)O
分子式C17H14O5
分子量298.29
溶解度0.1 M Na2CO3: 4 mg/ml,DMF: 8 mg/ml,DMSO: 1 mg/ml,Ethanol: .5 mg/ml,PBS (pH 7.2): 0.34 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AH 6809 is an antagonist of prostaglandin receptor EP1, EP2 and D2 [1].

In COS-7 cells transfected with human EP2 receptor, AH 6809 treatment selectively inhibited the cAMP production increased by PGE2 but not forskolin. In the non-small cell lung cancer NCI-H1299 cell line, AH 6809 inhibited the binding of3H-PGE2 to the cell membrane with IC50 value of 5 μM. The compound also inhibited the increase in cAMP level caused by PGE2 in NCI-H1299 cells. Moreover, AH 6809 significantly suppressed the cell proliferation and colony formation at low micromolar concentration. Besides that, AH 6809 exerted to be a specific DP-receptor blocking drug. It inhibited the anti-aggregation activity of PGD2 in whole blood [1, 2 and 3].

References:
1. Woodward D F, Pepperl D J, Burkey T H, et al. 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2receptor antagonist. Biochemical pharmacology, 1995, 50(10): 1731-1733.
2. Qian X, Zhang J, Liu J. Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway. Journal of Biological Chemistry, 2011, 286(3): 2111-2120.
3. Ito S, Okuda E, Sugama K, et al. Evaluation of ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea. British journal of pharmacology, 1990, 99(1): 13-14.