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Efaproxiral Sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Efaproxiral Sodium图片
CAS NO:170787-99-2
包装:50mg
市场价:494元

产品介绍
Efaproxiral sodium (RSR13 sodium) 是一种合成的血红蛋白 (Hb) 变构调节剂,在放射治疗期间降低 Hb-氧 (O2) 结合亲和力并增强缺氧肿瘤的氧合。
Cas No.170787-99-2
别名乙丙昔罗钠,RSR13 sodium
化学名sodium;2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoate
Canonical SMILESCC1=CC(=CC(=C1)NC(=O)CC2=CC=C(C=C2)OC(C)(C)C(=O)[O-])C.[Na+]
分子式C20H23NO4.Na
分子量363.38
溶解度≥ 18.4 mg/mL in DMSO, ≥ 12.83 mg/mL in Water with ultrasonic, ≥ 18.45 mg/mL in EtOH
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.

References:
[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.