Buspirone hydrochloride 是一种 5HT(1A) 受体激动剂，可用于研究广泛性焦虑症。

Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).

Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. [1] Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine. [2]

33386-08-2

C21H32ClN5O2

421.97

Buspirone HCl;Narol;盐酸丁螺环酮;Buspar

DMSO:42.2 mg/mL (100 mM)
H2O:42.2 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years