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Buspirone hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Buspirone hydrochloride图片
CAS NO:33386-08-2
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Buspirone HCl
Narol
盐酸丁螺环酮
Buspar
产品介绍
Buspirone hydrochloride 是一种 5HT(1A) 受体激动剂,可用于研究广泛性焦虑症。

产品描述

Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).

体外活性

Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. [1] Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine. [2]

Cas No.

33386-08-2

分子式

C21H32ClN5O2

分子量

421.97

别名

Buspirone HCl;Narol;盐酸丁螺环酮;Buspar

储存和溶解度

DMSO:42.2 mg/mL (100 mM)
H2O:42.2 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years