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(R,S)-Tetrahydropalmatine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:10097-84-4
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
罗通定,延胡索乙素
Tetrahydropalmatine hydrochloride
产品介绍
Rotundine 是从延胡索 W. T. Wang 中提取的。

产品描述

Rotundine is extracted from Corydalis yanhusuo W. T. Wang.

体外活性

Rotundine displays a higher affinity to dopamine D1 than D2 receptor with Ki of 124 nM and 388 nM, respectively, while the IC50 values are 166 nM (D1) and 1.47 μM (D2), respectively. Rotundine exhibits a weak inhibitory activity against dopamine D3 with IC50 of 3.25 μM. Rotundine also potently inhibits 5-HT1A with IC50 of 374 nM and Ki of 340 nM. In addition to the antagonism of postsynaptic dopamine receptors, inhibition of presynaptic autoreceptors by Rotundine leads to increased dopamine release, which is probably attributed to lower affinity of Rotundine for D2 receptors. Along with dopamine receptors, Rotundine can interact with a number of other receptor types, including α-1 adrenergic receptors, at which it functions as an antagonist, and γ-aminobutyric acid receptors, at which it facilitates γ-aminobutyric acid binding through positive allosteric effects. [1]

Cas No.

10097-84-4

分子式

C21H25NO4

分子量

355.43

别名

罗通定,延胡索乙素;TETRAHYDROPALMATINE HYDROCHLORIDE

储存和溶解度

DMSO:8 mg/mL (22.5 mM)
H2O:<1 mgml
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years