| CAS NO: | 1380716-06-2 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1380716-06-2 |
| 分子式 | C17H14N4O |
| 分子量 | 290.32 |
| 溶解度 | DMSO : 5 mg/mL (17.22 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60℃) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts[1].ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1]. [1]. Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. |
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