| CAS NO: | 128-13-2 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| Cas No. | 128-13-2 |
| 别名 | 熊去氧胆酸; Ursodeoxycholate; Ursodiol; UDCA |
| 化学名 | (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid |
| Canonical SMILES | CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C |
| 分子式 | C24H40O4 |
| 分子量 | 392.57 |
| 溶解度 | ≥ 16mg/mL in DMSO |
| 储存条件 | Store at 4°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ursodiol (Ursodeoxycholic acid) is bile acids used in treatment of primary biliary cirrhomized (PBC) [1]. Ursodiol (Ursodeoxycholic acid) has been reported to prevent progression of PBC, and increase survival. In addition, Ursodiol has been revealed to inhibit the initiation and postinitiation phases of azoxymethane-induced colonic tumor development. Moreover, Ursodiol has been noted to dose-dependently inhibit the viability of HepG2 and BEL7402 cell lines with IC50 values of 0.92mmol/L and 0.86mmol/L, respectively. Ursodiol has also reported to dose-dependently and significantly enhance the apoptosis rates in HepG2 and BEL7402 cells. Besides, treatment of Ursodiol has shown the reduction of the ecpression of cell cycle regulating proteins (cyclinD1,cyclin D3, Cdk2 and Cdk4) in Western blot analysis [1]. References: |
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