MD 69276 是可逆的单胺氧化酶 A (MAOA) 抑制剂，是一种抗抑郁剂。

MD 69276 (Toloxatone) is a reversible monoamine oxidase A (MAOA) inhibitor.

The maximum increase in systolic blood pressure produced by four single oral doses of tyramine administered during a meal and ranging from 100 mg to 800 mg was compared during repeated (3 to 5 days) administration of placebo, 200 mg toloxatone three times a day and 400 mg toloxatone three times a day in a single-blind, three-period crossover study. Toloxatone by itself had no significant influence on blood pressure. During administration of toloxatone, no significant increase in tyramine-induced increase in systolic blood pressure was observed for tyramine doses of 200 mg or less that are consistently higher than those associated with normal food intake [2].

29218-27-7

C11H13NO3

207.229

托洛沙酮;MD 69276

DMSO:50 mg/mL (241.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years