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Lisinopril dihydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lisinopril dihydrate图片
CAS NO:83915-83-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
赖诺普利二水合物(MK-521 二水合物)是血管紧张素转换酶抑制剂,用于治疗高血压、充血性心力衰竭和心脏病发作。
Cas No.83915-83-7
别名赖诺普利二水合物; MK-521 dihydrate
化学名(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate
Canonical SMILESC1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
分子式C21H35N3O7
分子量441.52
溶解度<4.42mg/mL in DMSO
储存条件Store at 2-8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lisinopril is a long-acting inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 4.7nM [1].

Lisinopril is a lysine analogue of MK 421. Both of them are the inhibitors of ACE and found to significantly inhibit the pressor response to exogenous angiotensin I. The administration of lisinopril can lower the diastolic and systolic blood pressure and higher the heart rate. Lisinopril is found to reduce the activity of plasma angiotensin converting enzyme markedly. It increases the level of plasma rennin while decreases the levels of plasma Angiotensin II and aldosterone. Lisinopril is a drug now used for many disorders including hypertension, heart failure, acute myocardial infarction and diabetic nephropathy. lisinopril dehydrate is the commercial form of this drug [2, 3].

References:
[1] Arora P K, Chauhan A. ACE INHIBITORS: A COMPREHENSIVE REVIEW. International Journal of Pharmaceutical Sciences & Research, 2013, 4(2).
[2] Brunner DB, Desponds G, Biollaz J, Keller I, Ferber F, Gavras H, Brunner HR, Schelling JL. Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects. Br J Clin Pharmacol. 1981 May;11(5):461-7.
[3] Sorrenti M, Catenacci L, Cruickshank DL, Caira MR. Lisinopril dihydrate: single-crystal x-ray structure and physicochemical characterization of derived solid forms. J Pharm Sci. 2013 Oct;102(10):3596-603.