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4-Chlorophenylguanidine hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-Chlorophenylguanidine hydrochloride图片
CAS NO:14279-91-5
包装:100mg
市场价:2867元

产品介绍
Urokinase inhibitor, potent and specific
Cas No.14279-91-5
别名洗必泰二乙酸杂质
化学名2-(4-chlorophenyl)guanidine;hydrochloride
Canonical SMILESC1=CC(=CC=C1N=C(N)N)Cl.Cl
分子式C7H8ClN3.HCl
分子量206.07
溶解度Soluble to 100 mM in Water
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].

Urokinase is a serine protease. Its primary physiological substrate is plasminogen, which is an inactive form of plasmin. Urokinase plays an important role in vascular diseases and cancer.

4-Chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with Ki value of 6.07 μM and 120 μM, respectively [1].

Reference:
[1].  Yang H, Henkin J, Kim KH, et al. Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. J Med Chem, 1990, 33(11): 2956-2961.