| CAS NO: | 101-26-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 电议 |
| 500mg | 电议 |
| 1 g | 电议 |
| 5 g | 电议 |
| Cas No. | 101-26-8 |
| 别名 | 溴化吡啶斯的明 |
| 化学名 | (1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate;bromide |
| Canonical SMILES | C[N+]1=CC=CC(=C1)OC(=O)N(C)C.[Br-] |
| 分子式 | C9H13BrN2O2 |
| 分子量 | 261.12 |
| 溶解度 | ≥ 13.056mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.Target: AChEPyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood–brain barrier, except possibly in stressful conditions. Pyridostigmine bromide inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. It is a quaternary carbamate inhibitor of cholinesterase that does not cross the blood–brain barrier which carbamylates about 30% of peripheral cholinesterase enzyme. The carbamylated enzyme eventually regenerates by natural hydrolysis and excess ACh levels revert to normal.Pyridostigmine bromide is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome. Pyridostigmine bromide sometimes is used to treat orthostatic hypotension. It may also be of benefit in chronic axonal polyneuropathy. References: |
m.cnreagent.com