| CAS NO: | 24219-97-4 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 100mg | 电议 |
| Cas No. | 24219-97-4 |
| 别名 | 米安色林; Mianserine |
| 化学名 | (R)-3-methyl-1,2,3,4,4a,9-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine |
| Canonical SMILES | [H]C1(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C3=C([H])C([H])=C([H])C([H])=C43)N4C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] |
| 分子式 | C18H20N2 |
| 分子量 | 264.36 |
| 溶解度 | Soluble in DMSO; >16 mg/mL in DMSO; >50 mg/mL in Methanol with ultrasonic; >10 mg/mL in EtOH with ultrasonic |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | Mianserin is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.Target: H1 receptorMianserin is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects. It is not approved for use in the US, but its analogue, mirtazapine, is. Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose.Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, and α2-adrenergic receptors, and also inhibits the reuptake of norepinephrine. As a high affinity H1 receptor inverse agonist, mianserin has strong antihistamine effects (sedation, weight gain, etc.). Contrarily, it has negligible affinity for the mACh receptors, and thus lacks any anticholinergic properties. It was recently found to be a potent kappa opioid receptor agonist. In addition, mianserin also appears to be a potent antagonist of the neuronal octopamine receptor. What implications this may have on mood are currently unknown, however octopamine has been implicated in the regulation of sleep, appetite and insulin production and therefore may theoretically contribute to the overall side effect profile of mianserin. References: |
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