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(S)-(+)-Ibuprofen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-(+)-Ibuprofen图片
CAS NO:51146-56-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
200mg电议

产品介绍
(S)-(+)-Ibuprofen ((S)-Ibuprofen) 是布洛芬的 S(+)-对映异构体,是一种有效的 COX-1 和 COX-2 抑制剂,IC50 为 2.1 μM,分别为 1.6 μM。
Cas No.51146-56-6
别名(S)-(+)-布洛芬; (S)-Ibuprofen
化学名(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
Canonical SMILESCC(C)CC1=CC=C(C=C1)C(C)C(=O)O
分子式C13H18O2
分子量206.28
溶解度DMF: 30 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

References:
[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.
[2]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52.