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Ractopamine(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ractopamine(hydrochloride)图片
CAS NO:90274-24-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1 g电议

产品介绍
A TAAR1 agonist
Cas No.90274-24-1
别名盐酸莱克多巴胺
Canonical SMILESOC1=CC=C(C(O)CNC(C)CCC2=CC=C(O)C=C2)C=C1.Cl
分子式C18H23NO3 • HCl
分子量337.8
溶解度DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ractopamine is a trace amine-associated receptor 1 (TAAR1) agonist.1It increases chloride conductance inX. laevisoocytes expressing the human cystic fibrosis transmembrane conductance regulator (CFTR) and mouse TAAR1 (EC50= 16 µM), an effect that can be blocked by the TAAR1 antagonist EPPTB . It selectively induces chloride conductance in TAAR1- and CFTR-expressing oocytes over those expressing the human β2-adrenergic receptor (β2-AR) and CFTR at 36 µM. However, it is also considered a β2-AR agonist that binds to β2-ARs (Ki= 0.18 µM for the recombinant human receptor expressed in Sf9 cells) and induces relaxation of isolated guinea pig trachea with an EC50value of 9.1 nM.2Formulations containing ractopamine have been used as food additives in livestock to increase weight gain and leanness and improve feed efficiency.

1.Liu, X., Grandy, D.K., and Janowsky, A.Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1J. Pharmacol. Exp. Ther.350(1)124-129(2014) 2.Kern, C., Meyer, T., Droux, S., et al.Synthesis and pharmacological characterization of β2-adrenergic agonist enantiomers: ZilpaterolJ. Med. Chem.52(6)1773-1777(2009)